5-Amino-1MQ Research Profile: Investigating NNMT Blockade and Cellular Energy Homeostasis
5-Amino-1-methylquinolinium (5-Amino-1MQ) is a selective, membrane-permeable small-molecule inhibitor targeting Nicotinamide N-methyltransferase (NNMT), a cytosolic enzyme that catalyzes the transfer of a methyl group from S-adenosyl-L-methionine ($SAM$) to nicotinamide ($NAM$). In 2026 life sciences research, this compound serves as a vital biochemical tool to study adipocyte metabolism, muscle tissue degeneration models, and the regulation of epigenetic histone methylation. By blocking NNMT activity, this reagent allows investigators to monitor localized shifts in the $NAD^+$ salvage pathway and cellular respiration efficiency. Institutions choosing to buy 5-Amino-1MQ online trust Peptide Crafters for analytical transparency and batch-specific lab reports.
Molecular Specifications
| Parameter | Specification |
| Chemical Identification | 5-Amino-1-methylquinolinium |
| Molecular Formula | $C_{10}H_{11}N_{2}^+$ (Base Cationic Form) |
| Molecular Weight | $159.21\ g/mol$ (Free Cation) |
| CAS Number | 42464-96-0 |
| Structure | Quinolinium derivative small-molecule kinase/methyltransferase probe (Acetate Salt matrix) |
| Purity Grade | 99%+ Analytical Standard |
Pharmacokinetic Horizons
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Enzymatic Interception and Ligand-Receptor Affinity: 5-Amino-1MQ is extensively utilized for Analyzing the binding affinity at the cytosolic nicotinamide N-methyltransferase (NNMT) catalytic complex, evaluating how the quinolinium core sits within the substrate-binding pocket to competitively displace nicotinamide and block methyl-group transfers.
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Small-Molecule Permeability and Proteolytic Mitigation: As a low-molecular-weight organic compound rather than a standard linear polypeptide, 5-Amino-1MQ exhibits a distinct form of Proteolytic Mitigation. It completely bypasses degradation by extracellular proteases and endopeptidases, ensuring excellent structural half-life and cellular entry during in-vitro cell-culture incubation assays.
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Mitochondrial Oxygen Flux and Cellular Transduction Cascades: Investigations focus heavily on downstream Cellular Transduction cascades induced by NNMT inhibition, tracking the upregulation of sirtuin-1 ($SIRT1$) activity, the amplification of intracellular $NAD^+$ pools, and the acceleration of adenosine triphosphate ($ATP$) synthesis through oxidative phosphorylation.
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