ARA-290 Research Profile: Investigating Innate Repair Receptor Signaling and Tissue Cytoprotection
ARA-290 (Cibinetide) is a synthetic linear peptide derived from the non-erythropoietic structural domain of erythropoietin ($EPO$). In 2026 life sciences research, this ligand serves as a key biochemical model to isolate anti-inflammatory and tissue-protective actions from classic erythropoiesis. Because it lacks erythropoietic receptor affinity, ARA-290 is heavily utilized to evaluate cellular survival, peripheral nerve protection, and wound healing kinetics in cellular injury cultures. Institutions choosing to buy ARA-290 online trust Peptide Crafters for analytical transparency and batch-specific lab reports.
Molecular Specifications
| Parameter | Specification |
| Amino Acid Sequence | $pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser$ |
| Molecular Formula | $C_{51}H_{84}N_{16}O_{21}$ |
| Molecular Weight | $1257.3\ g/mol$ |
| CAS Number | 1208241-01-3 |
| Structure | Synthetic linear N-terminal pyroglutamate peptide (Acetate Salt) |
| Purity Grade | 99%+ Analytical Standard |
Pharmacokinetic Horizons
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Selective Ligand-Receptor Affinity for the Innate Repair Receptor: ARA-290 is specialized for Analyzing the binding affinity at the Innate Repair Receptor (IRR) complex, which consists of a erythropoietin receptor monomer coupled with a common beta chain ($EPOR-\beta_cR$) heterocomplex, avoiding activation of homodimeric $EPOR-EPOR$ pathways.
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N-Terminal Stabilization and Proteolytic Mitigation: The integration of an N-terminal pyroglutamic acid residue provide targeted Proteolytic Mitigation against rapid degradation by serum aminopeptidases, optimizing structural integrity and baseline kinetics during in-vitro incubation parameters.
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Intracellular Cellular Transduction Shielding Cascades: Research details the peptide’s downstream Cellular Transduction mechanisms, tracking how IRR signaling blocks the activation of the p38 mitogen-activated protein kinase (MAPK) and nuclear factor-kappa B ($NF-\kappa B$) pathways to modulate proinflammatory cytokine production.
Why Procure from Peptide Crafters?
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ISO-Certified HPLC Identification: Every batch of our cytoprotective ligands undergoes strict reverse-phase high-performance liquid chromatography and electrospray ionization mass spectrometry to ensure absolute sequence uniformity.
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Institutional Procurement Compliance: While research operations frequently implement a peptide crafters coupon code or a peptide crafters discount code to optimize laboratory allocations, our primary value rests on strict USP 71/85 sterilization and endotoxin protocols.
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