Kisspeptin-10 Research Profile: Investigating Kiss1R Agonism and Neuroendocrine Regulation
Kisspeptin-10 (metastin fragment 45-54) represents a foundational biochemical tool for analyzing the mammalian reproductive axis. As the minimal sequence required for high-affinity activation of the Kiss1 receptor, this peptide is extensively studied for its capacity to initiate the downstream secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) via hypothalamic networks. Institutions choosing to buy Kisspeptin-10 online trust Peptide Crafters for analytical transparency and batch-specific lab reports.
Molecular Specifications
| Parameter | Specification |
| Amino Acid Sequence | $Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH_2$ |
| Molecular Formula | $C_{63}H_{78}N_{14}O_{13}$ |
| Molecular Weight | $1302.4\ g/mol$ |
| CAS Number | 374675-21-5 |
| Structure | Synthetic linear decapeptide (C-terminal amidated) |
| Purity Grade | 99%+ Analytical Standard (Acetate Salt) |
Pharmacokinetic Horizons
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High Ligand-Receptor Affinity for Kiss1R: Kisspeptin-10 is primarily utilized for Analyzing the binding affinity at the Kiss1R (GPR54) complex, exploring the $G\alpha_{q/11}$-coupled phospholipase C activation pathway within GnRH-secreting neuroendocrine models.
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Proteolytic Mitigation and Half-Life Optimization: Research focus centers on the Proteolytic Mitigation of C-terminal amidated fragments, investigating the structural stability of the core decapeptide backbone when exposed to tissue-specific endopeptidases during in-vitro assays.
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Intracellular Cellular Transduction Cascades: Studies utilize this ligand to investigate the downstream Cellular Transduction of extracellular signal-regulated kinase 1 and 2 (ERK1/2) and arachidonic acid release mechanisms in localized cellular environments.
Why Procure from Peptide Crafters?
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ISO-Certified HPLC Identification: Every batch from this peptide crafter is subjected to precise validation protocols to ensure strict sequence conformity and zero structural variance.
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60-Day Money-Back Quality Guarantee: We provide an uncompromising risk-free assurance period, reflecting the precision of our lab tested peptides.
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Vacuum-Sealed Lyophilized Preservation: Our vials undergo state-of-the-art moisture extraction, ensuring maximum molecular stasis when you buy peptides online.
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Institutional Standards: While laboratories may utilize a peptide crafters discount code to support strategic funding, our core value remains our adherence to USP 85 endotoxin limits, ensuring optimal reproducibility for peptidecrafters clients.
For comprehensive data on our neuroendocrine ligands, visit the official peptide crafters catalog. By applying a peptide crafters discount code at checkout, institutional procurement teams can secure clinical-grade reagents while maintaining laboratory fiscal efficiency.
Research Use Only: All Peptide Crafters products are strictly for in-vitro laboratory research. Not for human or veterinary use. Communication regarding bodily administration will result in an immediate account termination.
