MOTS-c Research Profile: Investigating Mitochondrial Signaling and AMPK Activation Mechanisms
MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA Type-c) is a naturally occurring 16-amino acid peptide encoded by the mitochondrial genome rather than the nuclear genome. In 2026 life sciences research, this specialized peptide serves as a critical biochemical tool for exploring retrograde mitochondrial-nuclear signaling, cellular respiration adaptation, and cellular longevity frameworks. By mimicking endogenous metabolic stress responses, this linear polypeptide allows investigators to monitor systemic transcriptomic changes and energy expenditures within specialized skeletal muscle and metabolic cellular lineages. Institutions choosing to buy MOTS-c online trust Peptide Crafters for analytical transparency and batch-specific lab reports.
Molecular Specifications
| Parameter | Specification |
| Amino Acid Sequence | $Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Trp-Pro-Arg-Pro-Arg-Asn$ |
| Molecular Formula | $C_{101}H_{152}N_{28}O_{22}S_{2}$ |
| Molecular Weight | $2174.6\ g/mol$ |
| CAS Number | 1627580-64-6 |
| Structure | Synthetic linear single-chain mitochondrial polypeptide (Acetate Salt) |
| Purity Grade | 99%+ Analytical Standard |
Pharmacokinetic Horizons
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Retrograde Non-Classical Ligand-Receptor Affinity: MOTS-c is widely implemented for Analyzing the binding affinity at the specific metabolic enzyme complexes and nuclear transport structures, evaluating how the peptide translocates across the double-membrane mitochondrial barrier into the nucleus to bind with specific transcription factors under metabolic stress conditions.
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Targeted Primary Sequence and Proteolytic Mitigation: The specific structural layout of our synthesized MOTS-c sequence incorporates precision purification processing to provide Proteolytic Mitigation against rapid degradation by localized cytosolic proteases, extending the peptide’s structural integrity during mid-to-long-term incubation assays.
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AICAR-Mimetic Cellular Transduction Flux: Investigations track the downstream Cellular Transduction cascades mediated by MOTS-c, focusing on its ability to stimulate the 5′-adenosine monophosphate-activated protein kinase ($AMPK$) pathway, downregulate the folate cycle, and induce the accumulation of 5-aminoimidazole-4-carboxamide ribonucleotide ($AICAR$) to study cellular glucose transport mechanics.
Why Procure from Peptide Crafters?
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ISO-Certified HPLC Identification: Every sequential 15mg production lot from this peptide crafter undergoes thorough reverse-phase high-performance liquid chromatography and mass spectrometry profiling to establish absolute sequence integrity and structural purity.
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60-Day Money-Back Quality Guarantee: We back our entire scientific catalog with a robust 60-day replacement window, a quality standard consistently documented across positive peptide crafters reviews.
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Vacuum-Sealed Lyophilized Preservation: Reagents undergo state-of-the-art moisture extraction and deep-freeze preservation under sterile parameters to guarantee absolute matrix stability when you buy peptides online.
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Institutional Procurement Compliance: While research operations frequently implement a peptide crafters coupon code or a peptide crafters discount code to optimize laboratory allocations, our primary value rests on strict USP 71/85 sterilization and endotoxin protocols.
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Research Use Only: All Peptide Crafters products are strictly for in-vitro laboratory research. Not for human or veterinary use. Communication regarding bodily administration will result in an immediate account termination.
