LL-37 Research Profile: Investigating Cathelicidin-Mediated Membrane Permeabilization
LL-37 ($LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES$) represents the linear, amphipathic alpha-helical C-terminal fragment of the human cathelicidin antimicrobial peptide (hCAP18). In 2026 life sciences research, this 37-amino acid biomolecule serves as a foundational model for examining innate immune signaling, cytokine-independent inflammation modulation, and the physical disruption of anionic lipid bilayers. Institutions choosing to buy LL-37 online trust Peptide Crafters for analytical transparency and batch-specific lab reports.
Molecular Specifications
| Parameter | Specification |
| Amino Acid Sequence | $LLGDFFRKSKEKIGKEFKRIVQRIKDFLRNLVPRTES$ |
| Molecular Formula | $C_{205}H_{340}N_{60}O_{53}$ |
| Molecular Weight | $4493.3\ g/mol$ |
| CAS Number | 154947-66-7 |
| Structure | Synthetic amphipathic linear alpha-helical polypeptide (Acetate Salt) |
| Purity Grade | 99%+ Analytical Standard |
Pharmacokinetic Horizons
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Multimodal Ligand-Receptor Affinity and Lipopolysaccharide Inactivation: LL-37 is heavily utilized for Analyzing the binding affinity at the formyl peptide receptor-like 1 (FPRL1/FPR2) complex and the purinergic P2X7 receptor, tracking how its highly cationic sequence neutralizes bacterial lipopolysaccharides (LPS) to obstruct downstream endotoxin signaling cascades.
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Structural Self-Association and Proteolytic Mitigation: The peptide exhibits a unique propensity to self-associate into oligomers under physiological salt concentrations, a biochemical trait that provides intrinsic Proteolytic Mitigation against rapid breakdown by host serine proteases, ensuring sustained baseline structural integrity during long-term incubation assays.
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Pro-Inflammatory and Angiogenic Cellular Transduction Flux: Studies focus on the peptide’s secondary Cellular Transduction cascades, specifically mapping the transactivation of the epidermal growth factor receptor (EGFR) and the subsequent upregulation of mitogen-activated protein kinase (MAPK) pathways responsible for modeling angiogenesis and cell migration.
Why Procure from Peptide Crafters?
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ISO-Certified HPLC Identification: Every sequential production lot from this peptide crafter undergoes thorough high-performance liquid chromatography and mass spectrometry profiling to establish absolute sequence integrity and structural purity.
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60-Day Money-Back Quality Guarantee: We provide an uncompromising 60-day replacement window, a robust quality assurance baseline that forms the foundation of positive peptide crafters reviews across global life science institutions.
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Vacuum-Sealed Lyophilized Preservation: Reagents undergo state-of-the-art flash freezing and deep moisture extraction to maximize molecular shelf-life, ensuring pristine stability when you buy peptides online.
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Strict Institutional Security: While procurement teams routinely implement a peptide crafters coupon code or a peptide crafters discount code to optimize laboratory allocations, the foundational value rests on our strict adherence to USP 71/85 sterilization and endotoxin criteria.
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