FOXO4-DRI Research Profile: Investigating p53 Interaction Blockade and Senolysis Mechanisms
FOXO4-DRI (Forkhead box O4 D-Retro-Inverso) is a specially modified 44-amino acid peptide synthesized with D-amino acids in a reversed sequence order compared to the native FOXO4 part-sequence. In 2026 life sciences research, this structural architecture serves as a critical biochemical tool to examine cell-cycle arrest mechanisms and targeted senolysis. By competitively disrupting the endogenous interaction between FOXO4 and the p53 tumor suppressor protein, this reagent enables investigators to model the selective migration of p53 from the nucleus to the mitochondria, triggering transcription-independent apoptosis exclusively in senescent cell populations. Institutions choosing to buy FOXO4-DRI online trust Peptide Crafters for analytical transparency and batch-specific lab reports.
Molecular Specifications
| Parameter | Specification |
| Amino Acid Composition | D-retro-inverso isomer of FOXO4(86-133) containing D-enantiomers |
| Molecular Formula | $C_{227}H_{370}N_{74}O_{70}S_{2}$ |
| Molecular Weight | $5356.1\ g/mol$ |
| CAS Number | 2146142-99-8 |
| Structure | Linear D-retro-inverso polypeptide isomer (Acetate Salt matrix) |
| Purity Grade | 99%+ Analytical Standard |
Pharmacokinetic Horizons
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Disruptive Competitive Ligand-Receptor Affinity: FOXO4-DRI is highly utilized for Analyzing the binding affinity at the p53 tumor suppressor protein complex, mapping how the D-retro-inverso topology mimics the native binding interface to competitively detach p53 from nuclear FOXO4 anchors.
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Topological Reversal and Proteolytic Mitigation: The complete substitution with D-enantiomers coupled with reversed peptide-bond directionality provides absolute Proteolytic Mitigation against endogenous matrix metalloproteinases, trypsin, and intracellular endopeptidases, significantly extending its structural half-life in in-vitro serum assays.
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Mitochondrial Caspase Cellular Transduction Flux: Investigations track the downstream Cellular Transduction cascades initiated by nuclear p53 exclusion, specifically measuring outer mitochondrial membrane permeabilization, cytochrome c release, and the subsequent activation of caspase-3/7 pathways.
Why Procure from Peptide Crafters?
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ISO-Certified HPLC Identification: Every batch from this peptide crafter undergoes strict reverse-phase high-performance liquid chromatography and mass spectrometry to confirm the absolute stereo-purity and sequence inversion integrity of the isomer.
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60-Day Money-Back Quality Guarantee: We back our scientific catalog with an robust 60-day replacement window, a quality standard consistently documented across positive peptide crafters reviews.
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Vacuum-Sealed Lyophilized Preservation: Reagents undergo state-of-the-art moisture extraction and deep-freeze preservation under sterile parameters to guarantee absolute matrix stability when you buy peptides online.
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Strict Institutional Security: While procurement teams routinely implement a peptide crafters coupon code or a peptide crafters discount code to optimize laboratory allocations, the foundational value rests on our strict adherence to USP 71/85 sterilization and endotoxin criteria.
For comprehensive sequence packages and automated bulk logistics, navigate to the official peptide crafters catalog portal. Entering an active peptide crafters coupon code during checkout enables purchasing teams to obtain clinical-grade compounds while maintaining precise alignment with expected financial boundaries, supported by industry-best peptide crafters reviews.
Research Use Only: All Peptide Crafters products are strictly for in-vitro laboratory research. Not for human or veterinary use. Communication regarding bodily administration will result in an immediate account termination.
