Epitalon (Epithalon) Research Profile: Investigating Telomerase Activation and Epigenetic Remodeling
Epitalon (also known as Epithalon) is a synthetic tetrapeptide ($Ala-Glu-Asp-Gly$) modeled after epithalamin, a natural peptide bioregulator secreted by the pineal gland. In 2026 life sciences research, this molecule serves as a critical biochemical tool for exploring the mechanics of cellular senescence. Investigational priorities focus on its capability to cross cellular and nuclear membranes to interact with chromosomal structures, stimulate telomerase activity, and modulate melatonin secretion patterns in cellular cultures without modifying baseline genomic sequences. Institutions choosing to buy Epitalon (Epithalon) online trust Peptide Crafters for analytical transparency and batch-specific lab reports.
Molecular Specifications
| Parameter | Specification |
| Amino Acid Sequence | $Ala-Glu-Asp-Gly$ |
| Molecular Formula | $C_{14}H_{22}N_{4}O_{9}$ |
| Molecular Weight | $390.4\ g/mol$ |
| CAS Number | 307297-39-8 |
| Structure | Synthetic linear tetrapeptide monomer (Acetate Salt formulation) |
| Purity Grade | 99%+ Analytical Standard |
Pharmacokinetic Horizons
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Direct Chromatin Affinity and Nuclear Ligand-Receptor Affinity: Epitalon is heavily utilized for Analyzing the binding affinity at the specific promoter regions of the telomerase reverse transcriptase (TERT) gene complex, evaluating how the tetrapeptide interacts within the major groove of double-stranded DNA to induce epigenetic structural changes.
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Short-Chain Proteolytic Mitigation: Due to its ultra-short 4-amino acid structure, Epitalon exhibits specialized Proteolytic Mitigation against complex systemic endopeptidases that typically target larger, volatile polypeptides, resulting in high structural stability during in-vitro cellular incubation assays.
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Intracellular Cellular Transduction Flux: Investigations track the downstream Cellular Transduction mediated by Epitalon entry into the nucleus, focusing on the ribosomal expression of telomerase enzymes, the rate of telomeric repeat synthesis ($TTAGGG$), and the downstream inhibition of p53/p21-dependent senescence pathways.
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Institutional Procurement Compliance: While research operations frequently implement a peptide crafters coupon code or a peptide crafters discount code to optimize laboratory allocations, our primary value rests on strict USP 71/85 sterilization and endotoxin protocols.
For comprehensive sequence packages and automated bulk logistics, navigate to the official peptide crafters catalog portal. Entering an authorized peptide crafters coupon code during checkout enables laboratories to secure clinical-grade reagents while maintaining strict internal fiscal boundaries, supported by industry-best peptide crafters reviews.
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