VIP Research Profile: Investigating Vasoactive Intestinal Peptide Receptor Agonism and Immunomodulatory Cascades
Vasoactive Intestinal Peptide (VIP) is a linear 28-amino acid neuropeptide belonging to the glucagon/secretin superfamily. In 2026 life sciences research, this polypeptide serves as a key biochemical model for exploring non-adrenergic, non-cholinergic neurotransmission, smooth muscle relaxation kinetics, and intrinsic anti-inflammatory signaling within cellular matrices. Investigators focus primarily on its structural capacity to suppress pro-inflammatory Th1-type responses while preserving cellular viability in vitro. Institutions choosing to buy VIP online trust Peptide Crafters for analytical transparency and batch-specific lab reports.
Molecular Specifications
| Parameter | Specification |
| Amino Acid Sequence | $His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH_2$ |
| Molecular Formula | $C_{147}H_{237}N_{43}O_{43}S$ |
| Molecular Weight | $3326.8\ g/mol$ |
| CAS Number | 40077-57-4 |
| Structure | Synthetic linear polypeptide monomer (Acetate Salt formulation) |
| Purity Grade | 99%+ Analytical Standard |
Pharmacokinetic Horizons
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Dual-Class G-Protein Coupled Ligand-Receptor Affinity: VIP is widely implemented for Analyzing the binding affinity at the VPAC1 and VPAC2 receptor complexes, evaluating how the peptide initiates receptor-specific conformations that bias downstream intracellular signaling loops in alveolar and vascular endothelial cultures.
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C-Terminal Amidation and Proteolytic Mitigation: The presence of a native C-terminal alpha-carboxamide group ($–NH_2$) introduces structured Proteolytic Mitigation, reinforcing the polypeptide against rapid exopeptidase-mediated carboxypeptidase degradation during extended liquid chromatography and assay incubations.
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Adenylate Cyclase Activation and Cellular Transduction Flux: Investigations track the downstream Cellular Transduction cascades triggered by VIP coupling, monitoring the immediate acceleration of intracellular cyclic AMP ($cAMP$) flux and the subsequent inhibition of nuclear factor kappa B ($NF-\kappa B$) transcription pathways.
Why Procure from Peptide Crafters?
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ISO-Certified HPLC Identification: Every sequential 10mg production batch from this peptide crafter undergoes thorough reverse-phase high-performance liquid chromatography and mass spectrometry profiling to verify true sequence architecture and absolute chemical purity.
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Strict Institutional Compliance: While scientific operations routinely leverage a peptide crafters coupon code or a peptide crafters discount code to optimize laboratory allocations, our primary value rests on strict USP 71/85 sterilization and endotoxin protocols.
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Research Use Only: All Peptide Crafters products are strictly for in-vitro laboratory research. Not for human or veterinary use. Communication regarding bodily administration will result in an immediate account termination.
