NAD+ (1000mg) Buffered – In large 8ml Vial [Lyophilized]

GLP-3 Research Profile: Investigating GIP/GLP-1/Glucagon Receptor Tri-Agonism

Glucagon-Like Peptide-3 (GLP-3), structurally classified under triple-agonist architecture, represents a vital 2026 life sciences model engineered to isolate and examine simultaneous co-agonism across distinct metabolic pathways. As a customized multi-receptor secretagogue, this 15mg configuration serves as a foundational platform for tracking the synergistic modulation of insulinotropic and glucagonotropic signaling cascades within cellular assays. Institutions choosing to buy GLP-3 online trust Peptide Crafters for analytical transparency and batch-specific lab reports.

Molecular Specifications

Parameter	Specification
Molecular Classification	Unimolecular GIP / GLP-1 / Glucagon Receptor Tri-Agonist
Molecular Formula	$C_{225}H_{348}N_{62}O_{68}$ (Base Structural Architecture)
Molecular Weight	$5014.6\ g/mol$
CAS Number	2828432-16-6
Structure	Synthetic linear multi-substituted polypeptide (Acetate Salt)
Purity Grade	99%+ Analytical Standard

Pharmacokinetic Horizons

• Simultaneous Multi-Target Ligand-Receptor Affinity: GLP-3 (R) is engineered for Analyzing the binding affinity at the GIP, GLP-1, and glucagon receptor heterocomplexes, mapping how a single peptide sequence maintains high-velocity recruitment across three independent G-protein coupled receptor frameworks without competitive steric hindrance.

• Structural Cross-Linking and Proteolytic Mitigation: The peptide’s backbone incorporates custom non-natural amino acid substitutions designed for optimal Proteolytic Mitigation. These specific chemical adjustments protect vulnerable peptide bonds from swift cleavage by neutral endopeptidases and dipeptidyl peptidase-IV (DPP-IV), extending experimental observation windows in cellular cultures.

• Intracellular Cellular Transduction Flux: Research focuses on downstream Cellular Transduction cascades, evaluating the synchronized mobilization of intracellular cyclic AMP ($cAMP$) and $Ca^{2+}$ ions to model balanced homeostatic signalling profiles without baseline structural breakdown interference.

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Research Use Only: All Peptide Crafters products are strictly for in-vitro laboratory research. Not for human or veterinary use. Communication regarding bodily administration will result in an immediate account termination.